P24, a glycogen synthase kinase 3 (GSK 3) inhibitor
نویسندگان
چکیده
منابع مشابه
Glycogen Synthase Kinase-3 (GSK-3)-Targeted Therapy and Imaging
Glycogen synthase kinase-3 (GSK-3) is associated with various key biological processes, including glucose regulation, apoptosis, protein synthesis, cell signaling, cellular transport, gene transcription, proliferation, and intracellular communication. Accordingly, GSK-3 has been implicated in a wide variety of diseases and specifically targeted for both therapeutic and imaging applications by a...
متن کاملGlycogen Synthase Kinase-3
1Department of Pathology and Centre for Neuroscience, The University of Melbourne and Mental Health Research Institute, Parkville, VIC 3010, Australia 2Neurosignalling Group, Garvan Institute for Medical Research, 384 Victoria St. Darlinghurst, Sydney, NSW 2010, Australia 3Membrane Biology Group, Centre for Integrative Physiology, University of Edinburgh, George Square, Edinburgh EH8 9XD, UK 4 ...
متن کاملInhibitory phosphorylation of glycogen synthase kinase-3 (GSK-3) in response to lithium. Evidence for autoregulation of GSK-3.
Glycogen synthase kinase-3 (GSK-3) is a critical, negative regulator of diverse signaling pathways. Lithium is a direct inhibitor of GSK-3 and has been widely used to test the putative role of GSK-3 in multiple settings. However, lithium also inhibits other targets, including inositol monophosphatase and structurally related phosphomonoesterases, and thus additional approaches are needed to att...
متن کاملGlycogen synthase kinase-3 (GSK-3) is regulated during Dictyostelium development via the serpentine receptor cAR3.
Glycogen synthase kinase-3 (GSK-3) is required during metazoan development to mediate the effects of the extracellular signal wingless/Wnt-1 and hence is necessary for correct cell type specification. GSK-3 also regulates cell fate during Dictyostelium development, but in this case it appears to mediate the effects of extracellular cAMP. By direct measurement of GSK-3 kinase activity during Dic...
متن کاملPLS (Partial Least Square) Study for GSK-3 (Glycogen synthase kinase-3) Inhibition by Indirubin Derivatives
GSK-3 (Glycogen synthase kinase-3) is a serine/threonine protein kinase involved in various physiological processes and its inhibitors have been evaluated as promising drug candidates for severe pathologies. In this paper a PLS regression analysis was used, to explore the relationship between field of descriptors (as independent variable) and biological activities (pIC50 as dependent variables)...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
سال: 2002
ISSN: 0925-4439
DOI: 10.1016/s0925-4439(01)00092-8